What is it Acic 200 tablets ?
Acic 200mg treats infections caused by the herpes simplex virus, including skin and mucous membrane infections such as genital herpes (both primary and recurrent) and herpes zoster (shingles). It is recommended for adults with severe forms of herpes who experience frequent recurrences to undergo prophylactic treatment.
When you must not take Acic 200 tablets ?
Do not use Acic 200 if you are hypersensitive to the active ingredient acyclovir, any other ingredients in the product, or valacyclovir.
What special precautions should I follow when taking Acic 200 tablets ?
Asic 200 should be used only after consulting a doctor in patients with immune system disorders .
The product contains lactose. If you have an intolerance to some sugars, consult your doctor before taking Acic 200 .
Which other products that influence the effect of Acic 200 tablets or can be influenced by the preparation?
Probenecid ( drug , increase the levels of uric acid in the blood) reduces the release of acyclovir in the kidneys, which can lead to increased half-life of acyclovir . Observed interactions with cimetidine .
How should consider children and adults with use of Acic 200 tablets ?
In adults, occurs more frequently renal impairment than other patients. Therefore, it is advisable to monitor renal function in this patient group. Patients should drink plenty of fluids when taking the tablets. If necessary, the physician will determine the dosage.
Precautions during pregnancy and lactation ?
If you need to take Acic 200 during pregnancy, you should carefully consider the benefits and risks.
After you take products containing acyclovir, the active ingredient is present in breast milk. Therefore, you should stop breastfeeding during treatment with Acic 200.
Driving vehicles or operating machinery.
No evidence of impaired driving or operating machines during treatment cAcic 200 .
Dosage , route and duration of administration :
Unless otherwise prescribed by Acic 200 by your doctor is recommended after dosage. Please adhere to the instructions for use , as otherwise Acic 200 will not work correctly.
Treatment of infections of herpes simplex virus
Take 1 tablet ( 200 mg of acyclovir ) 5 times a day at an interval of 4 hours. Continue treatment for 5 days, but consider extending it in cases of severe initial infections. In patients with severe immunodeficiency (e.g., bone marrow transplantation) or impaired absorption, double the dose to 400 mg. Initiate treatment as early as possible after the onset of infection.
Prophylaxis in patients with normal immunity
Immunologically healthy patients received 1 tablet Acic 200 ( 200 mg acyclovir ) 4 times a day every 6 hours , respectively Acic 200 2 tablets (400 mg atsikpovir ) at intervals of 12 hours between doses .
In some cases, an effective prophylactic dose of 1 tablet of Acic® three times a day (3 x 200 mg acyclovir) at intervals of 8 hours or 2 x 200 mg of acyclovir per day at intervals of 12 hours can also achieve the desired results.
If there is a re-infection, regardless of the total daily dose of 800 mg, and in the case of determining Herpes simplex-1 infections, administer an Acic 200 tablet (200 mg of acyclovir) during the day at 4-hour intervals for a period of 5 days. Then, repeat the aforementioned dose.
Periodically interrupt therapy at intervals of 6 to 12 months to allow for possible changes in disease progression.
Prevention of infections caused by Herpes Simplex Virus in immunocompromised patients
A single dose of 1 tablet Asyu200 (200 mg acyclovir ) for prophylaxis 4 times a day at intervals of 6 hours.
Treatment of Varicella and Herpes Zoster, caused by Varicella Zoster Virus
To treat varicella and herpes zoster infections, avoid taking 800 mg of acyclovir 5 times daily at 4-hour intervals. Treatment should continue for 7 days. Early treatment with acyclovir herpes zoster resulted in successful pain relief and may reduce the incidence of post-herpetic neuralgia .
In patients with severe immune deficiency – should be considered intravenous administration.
Treatment of patients with severe immunodeficiency, to 800 mg twice daily aciclovir 4 to 6 hours.
Severe immunosuppressed patients , e. after organ transplantation or patients with impaired intestinal absorption – single dose of 2 tablets Asic 200 (400 mg acyclovir ), 4 times a day at intervals of 6 hours. Particularly in patients with impaired intestinal absorption , can be administered as a dry substance acyclovir infusion.
The duration of prophylactic use depends on the duration of the risk period .
Described have been cases of resistance in immunosuppressive patients. : P.ri such patients should be adjusted dosage.
In patients with bone marrow transplantation , the dose / usually preceded by intravenous administration continued ^ ‘ Yang , but one meaty Treatment duration was 6 months.
Infection with Herpes Simplex Virus
Children over two years the adult dose ; Children under 2 years receive half of the adult dose .
Patients with renal insufficiency
Dosage in patients with renal insufficiency:
(pmol / l / mg / dl) Women / Men
> 550 /> 750 /
> 6.22 > 8.48
Dosage – A single dose of 200 mg aciclovir, corresponding to 1 tablet Asyu ® 200 2 times a day in 12 hours
10-25 ml / min
Dosage: 800 mg three times daily at 8-hour intervals
When and how you can take tablets ?
The tablets should be taken not chewed , with a sufficient amount of fluid (e.g. a glass of water ), preferably after the meal.
In patients with impaired renal function should be paying particular attention to the adoption of the necessary amount of fluids during treatment .
Taking Asic 200 should start as soon as possible after the first symptoms of the infection. Especially in cases of recurrent infections of herpes simplex intake Acic 200 should begin at the first symptoms of relapse (eg, pruritus, sensation of tension, the first bubbles ) .
Duration of treatment
The attending physician determines the duration of treatment.
For herpes simplex virus, the standard treatment duration is 5 days, but it may be extended in cases of severe initial infections.
In immunologically healthy patients, the duration of treatment for preventing herpes simplex virus infection depends on the severity of the disease and the frequency of relapses. Therapy should be periodically interrupted every 6-12 months to monitor for any changes in disease progression.
In patients with severe immune system impairment, the duration of prophylactic use is individually determined by a doctor, based on the severity of the condition.
Treatment of infections caused by varicella zoster virus continues for 7 days.
Do not expect intoxication after overdose Acic ® 200 . Upon single dose of 5 g of acyclovir are not registered symptoms of intoxication. Repeated oral administration of higher doses led to adverse reactions Digestive system – nausea , vomiting and CNS – headache, confusion . In case of overdose or strengthening of side effects , please consult your doctor.
If you take less than the prescribed dose or you forget to take the product ?
Please continue treatment Acic ® 200 as prescribed ( please do not take more often or more tablets). If you forgot a few times or you take less than the prescribed amount Acic ® 200 , please consult your doctor.
Need to know if you have discontinued or have it terminated prematurely ?
Even if symptoms are relieved , treatment with Acic ® 200 should be continued as prescribed . If you are not sure – eg . due to the occurrence of side effects , please consult with your doctor before you stopped or advance after your treatment.
Which side effects can cause the application of Acic ® 200 tablets ?
Rarely been observed rash disappeared after discontinuation of the product , and gastrointestinal symptoms such as nausea , vomiting , diarrhea and abdominal pain .
Rarely symptoms related to the nervous system – dizziness, confusion, hallucinations and insomnia. These side effects usually occur in patients with impaired renal function or other diseases.
Rare cases of thinning hair (diffuse hair loss) have been reported, although the relationship to Acic® 200 is uncertain.
In rare cases, individuals have reported experiencing fatigue, headache, and insomnia.
Breathing difficulties have also been reported in rare cases. In some instances, individuals have reported dizziness and hallucinations, which disappear after discontinuing the product.
Observed were rare and temporary changes in some laboratory parameters of liver , kidney and blood counts (increase in bilirubin , liver enzymes, serum urea and creatinine , and a slight decrease in haematological parameters) .
Observed temporary convulsions and psychosis associated with intravenous acyclovir in complicated clinical situation. ,
If you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.
Tell your doctor if such reactions occur , to allow it to assess the extent and severity and , if necessary, take appropriate measures.
16. Additional Information
Storage Instructions :
Do not use after the expiry date stated on the packaging.
Keep out of reach of children .